Tramadol is an opioid analgesic drug has been used as an add-on treatment in adults and children. As precision of dosing and patient’s compliance become an important prerequisite for quick relief from analgesic there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling and better compliance. Hence, the present research work was held to develop a fast dissolving tablet of tramadol, prepared with Avicel PH 102 and sodium starch glycolate by direct compression method. All formulations were evaluated for characteristics such as hardness, friability, disintegration time and dissolution rate. An effective pleasant formulation was found to be having a good hardness of 4kg/cm2, disintegration time of 20±1 seconds and in-vitro drug release of not less than 98% within 3 minutes. The drug release was found to be comparable with the marketed dispersible tablet Trd-MD, of Mundi Pharmaceuticals.
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